pentobarbital will lessen the extent or result of linagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Use of different remedies is strongly recommended when linagliptin will be to be administered with a CYP3A4 inducerpentobarbital increases effects of ifosfamide by impacting hepatic enzyme CYP2B6 metabolism. U